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Solution NMR Analysis of Ligand Environment in Quaternary Ammonium-Terminated Self-Assembled Monolayers on Gold Nanoparticles: The Effect of Surface Curvature and Ligand Structure

https://doi.org/10.1021/jacs.8b11445

Wu, Meng; Vartanian, Ariane M.; Chong, Gene; Pandiakumar, Arun Kumar; Hamers, Robert J.; Hernandez, Rigoberto; Murphy, Catherine J. (February 2019, Journal of the American Chemical Society)

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Peripheral Membrane Proteins Facilitate Nanoparticle Binding at Lipid Bilayer Interfaces

https://doi.org/10.1021/acs.langmuir.8b02060

Melby, Eric S.; Allen, Caley; Foreman-Ortiz, Isabel U.; Caudill, Emily R.; Kuech, Thomas R.; Vartanian, Ariane M.; Zhang, Xi; Murphy, Catherine J.; Hernandez, Rigoberto; Pedersen, Joel A. (August 2018, Langmuir)

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Using an environmentally-relevant panel of Gram-negative bacteria to assess the toxicity of polyallylamine hydrochloride-wrapped gold nanoparticles

https://doi.org/10.1039/C7EN00832E

Buchman, Joseph T.; Rahnamoun, Ali; Landy, Kaitlin M.; Zhang, Xi; Vartanian, Ariane M.; Jacob, Lisa M.; Murphy, Catherine J.; Hernandez, Rigoberto; Haynes, Christy L. (January 2018, Environmental Science: Nano)

We aim to establish the effect of environmental diversity in evaluating nanotoxicity to bacteria. We assessed the toxicity of 4 nm polyallylamine hydrochloride-wrapped gold nanoparticles (PAH AuNPs) to a panel of bacteria from diverse environmental niches. The bacteria experienced a range of toxicities as evidenced by the different minimum bactericidal concentrations determined; the sensitivities of the bacteria was A. vinelandii = P. aeruginosa > S. oneidensis MR-4 > A. baylyi > S. oneidensis MR-1. Interactions between gold nanoparticles and molecular components of the cell wall were investigated by TEM, flow cytometry, and computational modeling. Binding results showed a general trend that bacteria with smooth lipopolysaccharides (LPS) bind more PAH AuNPs than bacteria with rough LPS. Computational models reveal that PAH migrates to phosphate groups in the core of the LPS structure. Overall, our results demonstrate that simple interactions between nanoparticles and the bacterial cell wall cannot fully account for observed trends in toxicity, which points to the importance of establishing more comprehensive approaches for modeling environmental nanotoxicity.
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Cascading Effects of Nanoparticle Coatings: Surface Functionalization Dictates the Assemblage of Complexed Proteins and Subsequent Interaction with Model Cell Membranes

https://doi.org/10.1021/acsnano.7b00231

Melby, Eric S.; Lohse, Samuel E.; Park, Ji Eun; Vartanian, Ariane M.; Putans, Rebecca A.; Abbott, Hannah B.; Hamers, Robert J.; Murphy, Catherine J.; Pedersen, Joel A. (May 2017, ACS Nano)

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Lipid Corona Formation from Nanoparticle Interactions with Bilayers

https://doi.org/10.1016/j.chempr.2018.09.018

Olenick, Laura L.; Troiano, Julianne M.; Vartanian, Ariane; Melby, Eric S.; Mensch, Arielle C.; Zhang, Leili; Hong, Jiewei; Mesele, Oluwaseun; Qiu, Tian; Bozich, Jared; et al (November 2018, Chem)

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Quantification of Free Polyelectrolytes Present in Colloidal Suspension, Revealing a Source of Toxic Responses for Polyelectrolyte-Wrapped Gold Nanoparticles

https://doi.org/10.1021/acs.analchem.6b04161

Qiu, Tian A.; Torelli, Marco D.; Vartanian, Ariane M.; Rackstraw, Nathan B.; Buchman, Joseph T.; Jacob, Lisa M.; Murphy, Catherine J.; Hamers, Robert J.; Haynes, Christy L. (February 2017, Analytical Chemistry)

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